protective effect of methanolic leaf extract of caesalpinia bonduc (l.) on gentamicin-induced hepatotoxicity and nephrotoxicity in rats

Authors

a. ali noorani

k. gupta

k. bhadada

m. k. kale

abstract

the present study was conducted to evaluate the protective effect of methanolic leaf extract of caesalpinia bonduc (l.) on gentamicin-induced hepatotoxicity and nephrotoxicity in rats . a control group (saline, group i, n = 6) was compared with rats administrated 80 mg/kg gentamicin, once daily for 7 days (groups ii, iii and iv). the effect of methanolic leaf extract of caesalpinia bonduc (group iii and iv) at a dose level of 250 mg/kg and 500 mg/kg was compared in gentamicin-induced hepatotoxicity and nephrotoxicity. the activities of serum alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp), triglyceride (tg), bilirubin, and total protein the values of urea, sodium, potassium and chloride were significantly increased in rats exposed to gentamicin. moreover, administration of gentamicin resulted in damage to liver and kidney structures. administration of methanolic extract of c.bonduc before gentamicin exposure prevented severe alterations of biochemical parameters and disruptions of liver and kidney structures. in conclusion, this study obviously demonstrated that pretreatment with methanolic extract of c.bonduc significantly attenuated the physiological and histopathological alterations induced by gentamicin. also, the present study identifies new areas of research for development of better therapeutic agents for liver, kidney, and other organs dysfunctions and diseases.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Protective Effect of Methanolic Leaf Extract of Caesalpinia Bonduc (L.) on Gentamicin-Induced Hepatotoxicity and Nephrotoxicity in Rats

The present study was conducted to evaluate the protective effect of methanolic leaf extract of Caesalpinia bonduc (L.) on gentamicin-induced hepatotoxicity and nephrotoxicity in rats . A control group (saline, group I, n = 6) was compared with rats administrated 80 mg/kg gentamicin, once daily for 7 days (groups II, III and IV). The effect of methanolic leaf extract of Caesalpinia ...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Protective Effect of Carica Papaya L. Seed Extract in Gentamicin Induced Hepatotoxicity and Nephrotoxicity in Rats

A study was conducted to evaluate the protective effect of aqueous seed extract of Carica papaya L. on gentamicin induced hepatotoxicity and nephrotoxicity in Wistar rats. A control group (Group I, n=12) was compared with rats administrated with 40 mg/kg gentamicin, once daily for 14 days (Groups II, III and IV, n=12 each). The effect of aqueous extract of Carica papaya L. at a dose level of 20...

full text

Protective effect of crocin on gentamicin-induced nephrotoxicity in rats

Objective(s): Gentamicin is used for the treatment of Gram-negative bacterial infections. However, gentamicin administration is limited because of nephrotoxicity. The aim of the present study was to evaluate the protective effect of crocin against gentamicin-induced nephrotoxicity in rats. Materials and Methods: Thirty two male Wistar rats received gentamicin (100 mg/kg, IP), with or without c...

full text

Protective Effect of Enicostemma littorale Blume Methanolic Extract on Gentamicin-Induced Nephrotoxicity in Rats

Problem statement: The Amino glycoside antibiotics cause drug induced nephrotoxicity at therapeutic doses and thus limits the use clinically. Oxidative stress is one of the main reasons for the development of nephrotoxicity. Approach: In light of this the aim of the present study was to investigate the role of mitochondrial as well as post-mitochondrial oxidative stress in the development of Ge...

full text

Protective Effects of Cinnamon Bark Hydroalcoholic Extract on Gentamicin-induced Nephrotoxicity in Mature Rats

Background and Methodology: Gentamicin is a broad-spectrum antibiotic with restricted application in man and stock due to its side effects such as Nephrotoxicity and autotoxicity. Cinnamon bark has antioxidant properties. This is the first study on the protective effects of the hydroalcoholic extract of cinnamon on gentamicin-induced nephrotoxicity.Methods and Materials: Thirty-six mature femal...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of pharmacology and therapeutics

جلد ۱۰، شماره ۱، صفحات ۲۱-۰

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023